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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
10 días laborables
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 10 |
| Mutation | exon 2 deletion in the COMMD1 gene |
| Mode of Inheritance | Autosómico recesivo |
| Organ | |
| Specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Also known as | Wilson disease |
Información específica de la prueba
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
Características clínicas
Los signos clínicos de daño hepático como resultado de la toxicosis por cobre pueden incluir hígado inflamado, anorexia, vómitos, letargo, pérdida de peso, ictericia e hinchazón del abdomen.
La toxicosis por cobre se puede mitigar con una dieta especializada baja en cobre y alta en zinc.
Información adicional
Although copper toxicosis in Bedlington Terriers was historically caused by a mutation in COMMD1, selection against this mutation has greatly reduced its prevalence in the breed. However, the ATP7B mutation was already present at low frequency and appears to have been inadvertently selected for. As a result, the ATP7B mutation is now more common than in the past and is responsible for most cases of copper toxicosis in modern Bedlington Terriers.
Referencias
Pubmed ID: 16293123
Year published: 2005
Omia ID: 1988
Omia variant ID: 643