€121,- €100,- IVA no incluido
Canine Degenerative Myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord.
25 días laborables
Especificaciones
| Breeds | Borzoi, Boyero de Berna, Caniche estándar, Corgi galés de Pembroke, Deerhound escocés, Fox Terrier de pelo de alambre, Glen Wicklow Terrier, Huski siberiano, Pastor Alemán, Pastor Australiano, Perro de San Huberto, Perro esquimal americano, Perro Pastor Shetland (Sheltie), Springer Spaniel Inglés, Airedale Terrier, Komondor, Spaniel de Agua Americano, Boxer, Boykin Spaniel, Cardigan Welsh Corgi, Cavalier King Charles Spaniel, Chesapeake Bay Retriever, Golden Retriever, Jack Russell Terrier, Kerry Blue Terrier, Labrador Retriever, Nova Scotia Duck Tolling Retriever, Pug, Rhodesian Ridgeback, Soft Coated Wheaten Terrier |
|---|---|
| Gene | |
| Organ | |
| specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Información específica de la prueba
Canine Degenerative Myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord. Neurodegenerative diseases are characterised by progressive loss of neurons in the central nervous system (CNS) which leads to deficiencies in function. In the case of DM, the affected region is the spinal cord, which results in ataxia (a loss of coordination). DM is similar in many ways to Amyotrophic Lateral Sclerosis (ALS) in humans.
This variant of the disease, sometimes designated as SOD1A or as Degenerative Myelopathy Exon 2, occurs in many different breeds. It is probely caused by an autosomal recessive mutation with incomplete penetrance to the gene SOD1. The variant is found in many breeds, but the disease is rarely diagnosed in breeds or in mixed-breed dogs other than those mentioned for this test.
For DM in Pembroke Welsh Corgis there are also multiple Degenerative Myelopathy Risk Modifiers (DMRM) descibed in literature. These SP110 mutations are available for testing in a different package.
Características clínicas
La mutación de la DM está presente en casi todas las razas de perros, pero en muchas razas no causa síntomas clínicos. La mayoría de los perros que podrían verse afectados tienen al menos 5 años de edad o más, al inicio de los signos clínicos que incluyen disminución de la fuerza en las patas traseras, incontinencia, hiporreflexia, espasticidad y ataxia de la pelvis con progresión con el tiempo hasta la parálisis completa.
Información adicional
Esta prueba es realizada por un laboratorio externo. CombiBreed se encarga de la mediación entre usted como cliente y el laboratorio externo. En este caso, CombiBreed no se hace responsable del comportamiento del cliente y/o contratista.
Referencias
Pubmed ID: 19188595
Omia ID: 263