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Sable is a hereditary coat colour pattern associated with a mutation in the melanocortin 1 receptor (MC1R; alpha melanocyte stimulating hormone receptor) gene, which influences the type of pigment produced in the hair.
10 días laborables
Only available in bundles
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 5 |
| Mutation | c.250G>A |
| Mode of Inheritance | Autosómico recesivo |
| Organ | |
| Specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Also known as | E-locus |
Información específica de la prueba
Sable is a hereditary coat colour pattern associated with a mutation in the melanocortin 1 receptor (MC1R; alpha melanocyte stimulating hormone receptor) gene, which influences the type of pigment produced in the hair. This variant /affect the normal switch between eumelanin (black/brown pigment) and phaeomelanin (red/yellow pigment), resulting in hairs that are lighter at the base with darker tips. This creates a reddish or golden coat with darker shading, often most noticeable on the ears, back, and tail. In English Cocker Spaniels, the inheritance pattern is most likely autosomal recessive.
Características clínicas
Affected dogs show a characteristic pattern of darker shading along the topline and over the shoulders, with shading that may extend down the sides of the body and the outer surfaces of the limbs. Individual hairs are banded, being lighter at the base and darker towards the tip, which creates a soft, blended appearance rather than a sharply defined pattern.
The head often shows clearer contrast, with darker shading on the crown and ears, while the muzzle and facial area are lighter. This can create the impression of a gradual transition on the face, which is typical of the sable pattern in English Cocker Spaniels.
Información adicional
El color del pelaje es un rasgo intrincado que implica una combinación de múltiples genes diferentes. Las pruebas para una variedad de loci diferentes darán la predicción más completa de la genética del color del pelaje de un perro.
Referencias
Pubmed ID: 38282569
Year published: 2024
Omia ID: 1199
Omia variant ID: 1681