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Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull.
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Especificaciones
| Breeds | Cairn Terrier, Scottish Terrier, West Highland White Terrier |
|---|---|
| Gene | |
| Chromosome | 5 |
| Mutation | c.1332C>T |
| Mode of Inheritance | Autosómico dominante con penetrancia incompleta |
| Organ | |
| Specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Also known as | CMO |
Información específica de la prueba
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull. Occurring in West Highland White Terriers, Scottish Terriers and Cairn Terriers, it is caused by a dominant mutation with incomplete penetrance to the Solute Carrier Family 37 Member 2 (SLC37A2) gene.
Because of its occurance in the West Highland White Terrier, the disorder is also known as Westie Jaw.
A closely related variant of the disorder is found in the Basset Hound.
Características clínicas
CMO comienza a manifestarse en perros afectados entre 4 y 8 meses de edad. Los signos incluyen hinchazón de la mandíbula, dificultad para abrir la mandíbula, dolor, falta de apetito y fiebre periódica. Las lesiones óseas se desarrollan en el cráneo, principalmente en la mandíbula. Los síntomas generalmente disminuyen cuando el perro ha terminado su período de crecimiento.
Información adicional
Referencias
Pubmed ID: 27187611
Year published: 2016
Omia ID: 2244
Omia variant ID: 411