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Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
10 días laborables
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Información específica de la prueba
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. The specific variant of the disease analysed in this test occurred in an Old English Sheepdog. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, German Shepherd, and the Rhodesian Ridgeback.
Características clínicas
La hemofilia A puede provocar hemorragias frecuentes de las articulaciones y los tejidos blandos. Los signos clínicos comunes en los perros incluyen sangrado de la boca, hematomas subcutáneos e intramusculares y cojera.
Información adicional
This variant seems to be a potentially spontaneous (de novo) recessive mutation found in one single Old English Sheepdog.
Referencias
Pubmed ID: 27780008
Omia ID: 437