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Polymyositis 1 (PM1) is a muscle disease in which inflammation of the muscles leads to difficulties with movement and swallowing.
15 días laborables
Especificaciones
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hisopo, sangre EDTA, sangre Heparina, Semen, Tejido |
| Mode of Inheritance | |
| Chromosome | |
| Also known as |
Información específica de la prueba
Polymyositis 1 (PM1) is a muscle disease in which inflammation of the muscles leads to difficulties with movement and swallowing. This variant occurs in the Dutch Kooikerhondje and is a complex genetic disorder involving multiple gene mutations. Dogs that are homozygous for this mutation have a minimum of 10% chance for developing the condition, while heterozygous animals have approximately a 1% chance.
Características clínicas
La enfermedad puede comenzar a una edad temprana, pero los síntomas y la gravedad varían mucho entre los perros. Los síntomas más notables incluyen una marcha anormal, debilidad muscular general y rigidez muscular. También puede haber dificultades para tragar. Además, pueden presentarse síntomas, como letargo, pérdida de peso, disminución de la resistencia y problemas respiratorios.
Información adicional
This DNA test is conducted in cooperation with the Expertise Centre Genetics of Companion Animals of Utrecht University.
Explanation of results:
WW = Your Kooikerhondje is clear of the risk factor for polymyositis. The dog is clear of the DNA variant that is involved in the development of polymyositis in the Kooikerhondje. This means that the risk of the disease is extremely low.
WM = Your Kooikerhondje is a heterozygote for the risk factor for polymyositis. The dog is a heterozygous carrier and has one copy of the DNA variant that is involved in the development of polymyositis in the Kooikerhondje. This means that the risk of the disease is limited at approximately 1%.
MM = Your Kooikerhondje is homozygous for the risk factor for polymyositis. The dog is homozygous for the risk factor and has two copies of the DNA variant that is involved in the development of the disease. Therefore, the dog has an increased risk to get polymyositis. The risk is estimated to be at least 10%. We advise to have the CK (= CPK) level of the blood of your dog measured at routine visits to your veterinarian. An increased level is indicative of polymyositis. Clinical signs that may be noticed are difficulty swallowing and difficulty walking with a stiff stride.
Referencias
Pubmed ID: University of Utrecht
Omia ID: