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Síndrome de Van den Ende-Gupta (VDEGS)

Van den Ende-Gupta Syndrome (VDEGS) is a hereditary skeletal disorder. It is due to an autosomal recessive mutation in the scavenger receptor class F, member 2 (SCARF2) gene, which plays a critical role in the bone mineralization and skeletal development. VDEGS is characterized by significant skeletal abnormalities such as joint luxations and related orthopedic issues. It is a rare but severe disorder that is primarily seen in Wire Fox Terriers.

Color de la capa Panda White Spotting

El Panda es una variación de color de la capa que añade manchas grandes y distintivas en blanco y negro al marrón normal del pelaje de un Pastor Alemán. Es el resultado de una mutación muy reciente en el gen KIT, que surgió por primera vez en el año 2000. El color del pelaje se hereda dominantemente; Sin embargo, se cree que la mutación es letal embrionaria, lo que significa que no nacerán cachorros con dos copias de la mutación.

Congenital Mirror Movement Disorder 1 (CMM1, EFNB3-related)

Congenital Mirror Movement Disorder 1 (CMM1) is an autosomal recessive movement disorder that affects the Weimaraner breed. In dogs with CMM1, nerve pathways in the spinal cord switch sides. This alteration prevents affected dogs from controlling each hind leg independently, leading to the characteristic bunny hopping gait. This gait might be occasionally observed in the front legs as well, though the primary focus is on the hind legs. The disorder is caused by a mutation in the EFNB3 gene that results in spinal cord malformations during embryonic development.

Trombastenia de Glanzmann (GT) 2 – Caballo

La trombastenia de Glanzmann (GT) es un trastorno hemorrágico causado por plaquetas defectuosas, lo que resulta en una incapacidad para que la sangre coagule adecuadamente. Esta variante de la enfermedad, que se encuentra en el Quarter Horse y el pura sangre, está causada por una mutación recesiva en el gen ITGA2B. Una variante relacionada también se encuentra en el Quarter Horse, así como en el Paso peruano.

Distrofinopatía en Labradoodle Australiano

Muscular Dystrophy (MD) is an X-linked muscular disorder, equivalent to Duchenne Muscular Dystrophy (DMD) in humans. The disorder is severe and ultimately fatal, and causes progressive degradation of the dog’s muscles. It is caused by an X-linked recessive mutation to the DMD gene.

The variant of the disorder analysed in this test is found in the Australian Labradoodle. It is also occasionally known as Australian Labradoodle Dystrophinopathy.

Coat Colour White Spotting – W4

El patrón de color del pelaje blanco dominante en los caballos puede ser causado por cualquiera de las mutaciones relacionadas. El patrón resultante puede variar desde marcas blancas en la cara y las piernas, hasta un pelaje completamente blanco. Dependiendo de la raza y el patrón, las variantes del fenotipo Blanco Dominante pueden denominarse Blanco Salpicado, Manchado Blanco, Tobiano o Sabino, entre otros.

La variante específica analizada en esta prueba, conocida como Blanco Dominante 4 (W4), está causada por una mutación dominante incompleta en el gen KIT. Se ha observado en el Caballo Blanco de Camarillo.

Trombastenia de Glanzmann (GT) 1 – Caballo

La trombastenia de Glanzmann (GT) es un trastorno hemorrágico causado por plaquetas defectuosas, lo que resulta en una incapacidad para que la sangre coagule adecuadamente. Esta variante de la enfermedad, encontrada en el Quarter Horse y el Paso Peruano, está causada por una mutación recesiva en el gen ITGA2B. Una variante relacionada también se encuentra en el Quarter Horse, así como en el Thoroughbred.

Random Parentage Verification 1-5 Kittens (Belgium)

With the Random Parentage Verification 1-5 Kittens (Belgium), you can verify the parentage of your kittens. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of one to five kittens, with one kitten randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the kittens and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected kitten against the alleged parents.
You will only receive a parentage verification report for the randomly tested kitten If the parentage of the randomly selected kitten is excluded, you need to request a parentage verification test for each individual kitten in the litter.

Random Parentage Verification 6-10 Kittens (Belgium)

With the Random Parentage Verification 6-10 Kittens (Belgium), you can verify the parentage of your kittens. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of six to ten kittens, with two kittens randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the kittens and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected kittens against the alleged parents.
You will only receive a parentage verification report for the randomly tested kittens If the parentage of the randomly selected kitten(s) is excluded, you need to request a parentage verification test for each individual kitten in the litter.

Random Parentage Verification >10 Kittens (Belgium)

With the Random Parentage Verification >10 Kittens (Belgium), you can verify the parentage of your kittens. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of ten kittens and more, with three kittens randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the kittens and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected kittens against the alleged parents.
You will only receive a parentage verification report for the randomly tested kittens If the parentage of the randomly selected kitten(s) is excluded, you need to request a parentage verification test for each individual kitten in the litter.

Random Parentage Verification 6-10 Puppies (Belgium)

With the Random Parentage Verification 6-10 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of six to ten puppies, with two puppies randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppies against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppies. If the parentage of the randomly selected puppy or puppies is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Random Parentage Verification >10 Puppies (Belgium)

With the Random Parentage Verification >10 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of ten pupies and more, with three puppies randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppies against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppies. If the parentage of the randomly selected puppy or puppies is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Coat Colour White Spotting – W18

El patrón de color del pelaje blanco dominante en los caballos puede ser causado por cualquiera de las mutaciones relacionadas. El patrón resultante puede variar desde marcas blancas en la cara y las piernas, hasta un pelaje completamente blanco. Dependiendo de la raza y el patrón, las variantes del fenotipo Blanco Dominante pueden denominarse Blanco Salpicado, Manchado Blanco, Tobiano o Sabino, entre otros.

La variación específica analizada en esta prueba, conocida como Dominant White 18 (W18), está causada por una mutación dominante incompleta en el gen KIT. Se ha observado en el Swiss Warmblood.

Random Parentage Verification 1-5 Puppies (Belgium)

With the Random Parentage Verification 1-5 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of one to five puppies, with one puppy randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppy against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppy. If the parentage of the randomly selected puppy is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Coat Colour White Spotting – W20

El patrón de color del pelaje blanco dominante en los caballos puede ser causado por cualquiera de las mutaciones relacionadas. El patrón resultante puede variar desde marcas blancas en la cara y las piernas, hasta un pelaje completamente blanco. Dependiendo de la raza y el patrón, las variantes del fenotipo Blanco Dominante pueden denominarse Blanco Salpicado, Manchado Blanco, Tobiano o Sabino, entre otros.

La variante específica analizada en esta prueba, conocida como Dominant White 20 (W20), está causada por una mutación dominante incompleta en el gen KIT. Se ha observado en una amplia variedad de razas de caballos.

Trombastenia de Glanzmann (GT) 2 – Perro

La Trombastenia de Glanzmann (GT) es un trastorno hemorrágico causado por plaquetas defectuosas, que puede provocar sangrado incontrolado. Esta variante de la enfermedad, la trombastenia de Glanzmann tipo I, está causada por una mutación recesiva en el gen ITGA2B. Se observa en los Gran Pirineo. Una variante relacionada se encuentra en el Scottish Deerhound.

Color de Capa Sabino 1

El patrón de color del pelaje blanco dominante en los caballos puede ser causado por cualquiera de las mutaciones relacionadas. El patrón resultante puede variar desde marcas blancas en la cara y las piernas, hasta un pelaje completamente blanco. Dependiendo de la raza y el patrón, las variantes del fenotipo Blanco Dominante pueden denominarse Blanco Salpicado, Manchado Blanco, Tobiano o Sabino, entre otros.

La variante específica analizada en esta prueba, conocida como Sabino 1 (SB1), está causada por una mutación dominante incompleta en el gen KIT. Se ha observado en el Cuarto de Milla Americano, Appaloosa, Haflinger, Lipizzaner y Noriker.

Leukodystrophy (LEP, TSEN54-related) – Schnauzer

Leukodystrophy is a class of neurological disorders in which the white matter of the brain degenerates, which can cause progressive signs such as a loss of coordination, tremors, limb weakness and potentially death. It is also known as Leukoencephalopathy (LEP). This variant of the disease, found in the Standard Schnauzer, is caused by a recessive mutation to the tRNA splicing endonuclease subunit 54 (TSEN54) gene.

Haemophilia A (HEMA-2) – German Shepherd

Haemophilia A, also known as Factor VIII Deficiency, is the most prevalent bleeding disorder in dogs. This X-linked recessive condition is triggered by a mutation in the gene F8, which severely compromises the blood’s clotting ability. Dogs affected by Haemophilia A may exhibit symptoms like spontaneous internal bleeding or uncontrolled bleeding following injuries or surgical procedures. These manifestations are a result of the impaired clotting mechanism in the bloodstream. As an X-linked recessive disorder, it predominantly affects male dogs, while female dogs usually act as carriers.
This specific variant of the disease (HEMA-2)occurs in the German Shepherd. Different variants of the mutation are found in other breeds including the Irish Setter, Miniature Schnauzer, Boxer, Old English Sheepdog and the Rhodesian Ridgeback.

Primary Open Angle Glaucoma (POAG) – Basset Hound

Primary Open Angle Glaucoma (POAG) is a bilateral eye disorder that results in increased pressure inside the eyes. It is often caused by problems in the trabecular meshwork (TM) and the anterior chamber (the front part of the eye), which impair the normal drainage of aqueous humour. This impaired drainage leads to elevated intraocular pressure (IOP), which damages the optic nerve and gradually leads to the death of retinal ganglion cells. As a result, the condition causes pain, progressive vision loss, and eventually blindness.

This variant of this disease, caused by a recessive mutation in the ADAMTS17 gene, occurs in the Basset Hound.

Similar variants have also been identified in the Basset Fauve de Bretagne, Petit Basset Griffon Vendéen, and the Chinese Shar-Pei.

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